Children - Definitions

    
Nephrotic Syndrome  

Massive proteinuria (> 40mg/m²/hr or a urine protein/creatinine ratio > 2.0 mg/mg), hypalbuminemia (<2.5 g/dl) and presence of edema
   
 Remission   Marked proteinuria reduction (to < 4 mg/m²/hr or urine albumine dipstick of 0 to trace for 3 consecutive days) in association with resolution of edema and normalization of serum albumine to at least 3.5 g/dl
   
Partial Remission   Still proteinuria (10-50mg/kg/d), serum albumine > 2.5 g/dl
     
Relapse   Recurrence of massive proteinuria (>40 mg/m²/hr, urine protein/creatinine ratio > 2.0 mg/mg, or urine albumine dipstick >= 2+ on 3 consecutive days), most often in association with recurrence of edema
     
Steroid Sensitivity   Remission in response to corticosteroid treatment
     
Steroid Resistance   No Reduction of Proteinuria despite adequate steroid therapy
     
 Steroid Dependence   Relaps while on therapy or requirement of continuation of steroids
     
     
    Reference: Gbadegesin R and Smoyer WE: Nephrotic syndrome 
In: Comprehensive Pediatric Nephrology, Geary D and Schaefer F (Eds). Elsevier, 2008