Diagnostic and Therapeutic Algorithms

The PodoNet Website provide evidence- and consensus-based clinical practice guidelines.
In the long-term, the aim is the harmonization of SRNS management in Europe.

     >     Proposed Clinical Management of Nephrotic Syndrome in Children and Adults

We suggest to initiate a standardized genetic diagnostic work-up of SRNS patients if not done so already: 

     >     Suggested Strategy of Genetic Mutation Screening in SRNS

Mitochondrial gene screening should be performed in SRNS patients if they meet any of the following criteria:
SRNS associated with neuro-muscular symptoms, deafness, endocrine disorders, retinopathy, cardiomyopathy,
SRNS with abnormal SDH and/or COX renal histochemistry and high urinary lactate and 3-OH-butyrate,
SRNS with abnormal mitochondria on electron micrography, SRNS with ubiquinone deficiency.

     >     Suggested Strategy of Mitochondrial Gene Screening in SRNS